Immunotherapy is a treatment that uses certain parts of a person’s immune system to fight diseases such as cancer. Immunotherapy works better for some types of cancer than others.
Cellular immunotherapy involves administering T cells to the patient to help fight diseases such as cancer.
During cancer treatment, T cells are removed from the patient’s blood or tumor tissue, produced in large numbers in the laboratory, and returned to the patient to help the immune system fight the cancer.
There are two main types of T-cell transfer therapy: tumor-infiltrating lymphocyte therapy (or TIL) and CAR T-cell therapy.
- LIT therapy uses T cells called tumor-infiltrating lymphocytes that are found in the tumor. The main objective of this procedure is that the lymphocytes that are inside or near the tumor are able to recognize the tumor cells. Giving large numbers of lymphocytes that are more responsive to the tumor can help overcome these obstacles.
- CAR T cell therapy, first the T cells are modified in the laboratory to make a type of protein known as CAR and given back to the body.
These CAR receptors allow T cells to bind to specific proteins on the surface of cancer cells, thereby enhancing their ability to attack them.
The cancers treated with these procedures would be the following:
Treatment of metastatic melanoma, because they cause a strong immune response and often have many TILs. The use of LIT therapy has been effective for some people with melanoma and has produced promising results in other cancers, such as squamous cell carcinoma of the cervix and cholangiocarcinoma. However, this treatment is still experimental. Also in the experimental phase as a treatment for breast cancer and brain cancer.
The symptoms of T cell therapy are:
CAR T cells: Fever, nausea, fast heartbeat, headache, rash, low blood pressure, and shortness of breath. In the case of LIT therapy, it can cause capillary leak syndrome consisting of multiple organ failure and cardiocirculatory shock.
Terms used:
Immunotherapy, in medicine, refers to the set of treatment strategies to stimulate or restore the immune system against cancer, infections or other diseases, as well as to reduce the side effects of very aggressive treatments used against cancer.
T-cells, also called T-lymphocytes, are produced in the bone marrow and later mature in the thymus, whose functions are an important part of the adaptive immune system.
Melanone is a form of cancer that begins in melanocytes.
Immune system or immune system is the set of elements and biological processes inside an organism that allows it to maintain homeostasis or internal balance against external aggressions, whether of biological or physicochemical and internal origin.
https://www.cancer.gov/espanol/publicaciones/diccionarios/diccionario-cancer/def/inmunoterapia-celular-adoptiva
https://www.cancer.gov/espanol/cancer/tratamiento/tipos/inmunoterapia/terapia-transferencia-de-celulas-t
https://www.cancer.org/es/tratamiento/tratamientos-y-efectos-secundarios/tipos-de-tratamiento/inmunoterapia/como-se-usa-la-inmunoterapia.html
https://es.wikipedia.org/wiki/Inmunoterapia
https://es.wikipedia.org/wiki/Linfocito_T
https://es.wikipedia.org/wiki/Sistema_inmunitario
https://www.cancer.gov/espanol/publicaciones/diccionarios/diccionario-cancer/def/melanoma
